Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement
(National Library of Medicine—MDPI nutrients: 2017)
Published Studies on the Efficacy of MSM (methylsulfonylmethane)
(Bergstrom Nutrition: 1985 to 2020)
Effects of Methylsulfonylmethane (MSM) on exercise-induced oxidative stress, muscle damage, and pain following a half-marathon: a double-blind, randomized, placebo-controlled trial - Background: Oxidative stress and muscle damage occur during exhaustive bouts of exercise, and many runners report pain and soreness as major influences on changes or breaks in training regimens, creating a barrier to training persistence. Methylsulfonylmethane (MSM) is a sulfur-based nutritional supplement that is purported to have pain and inflammation-reducing effects. To investigate the effects of MSM in attenuating damage associated with physical exertion, this randomized, double-blind, placebo-controlled study evaluated the effects of MSM supplementation on exercise-induced pain, oxidative stress and muscle damage.
(National Library of Medicine: 2017)
Beneficial Effects of a Sulfur-Containing Supplement on Hair and Nail Condition:
Methylsulfonylmethane (MSM) is an organosulfur compound that has been shown to be beneficial for joint health, sports nutrition, and immune function, as well as exerting antiaging effects. It is gaining popularity as a nutritional supplement for support of the hair, skin, and nails. In this double-blind clinical study, 63 subjects ingested either 1 g or 3 g of MSM per day. Expert clinical grading and subject self-assessment were used to evaluate hair and nail condition over 4 months of use. MSM supplementation provided statistically significant improvements in the condition of the hair and nails as determined by expert grading and subject self-assessment. The higher concentration (3 g/day) of MSM delivered quicker and stronger benefits, as compared to the lower concentration (1 g/day). MSM appears to benefit hair and nail health, possibly by its action on keratin, which is a major building-block for the hair and nails.
(Natural Medicine Journal: 2019)
Small Intestinal Absorption of Methylsulfonylmethane (MSM) and Accumulation of the Sulfur Moiety in Selected Tissues of Mice: The principal dietary sources of sulfur, the amino acids methionine and cysteine, may not always be consumed in adequate amounts to meet sulfur requirements. The naturally occurring organosulfur compound, methylsulfonylmethane (MSM), is available as a dietary supplement and has been associated with multiple health benefits. Absorption of MSM by the small intestine and accumulation of the associated sulfur moiety in selected tissues with chronic (8 days) administration were evaluated using juvenile male mice. Intestinal absorption was not saturated at 50 mmol, appeared passive and carrier-independent, with a high capacity (at least 2 g/d-mouse). The 35S associated with MSM did not increase in serum or tissue homogenates between days 2 and 8, indicating a stable equilibrium between intake and elimination was established. In contrast, proteins isolated from the preparations using gel electrophoresis revealed increasing incorporation of 35S in the protein fraction of serum, cellular elements of blood, liver, and small intestine but not skeletal muscle. The potential contributions of protein synthesis using labeled sulfur amino acids synthesized by the gut bacteria and posttranslational sulfation of proteins by incorporation of the labeled sulfate of MSM in 3′-phosphoadenosine 5′-phosphosulfate (PAPS) and subsequent transfer by sulfotransferases are discussed.
(National Library of Medicine—MDPI nutrients: 2018)
Beauty from within: Oral administration of sulfur-containing supplement methylsuflonylmethane improves signs of skin ageing: This study indicated that MSM is effective in reducing visual signs of skin ageing even at a low dose of 1 g/d.